CALL FOR PAPERS Computational Modeling of Physiological Systems Epistasis contributes to the genetic buffering of plasma HDL cholesterol in mice
نویسندگان
چکیده
Li RH, Churchill GA. Epistasis contributes to the genetic buffering of plasma HDL cholesterol in mice. Physiol Genomics 42A: 228 –234, 2010. First published September 21, 2010; doi:10.1152/physiolgenomics.00044.2010.—Stressful environmental factors, such as a high-fat diet, can induce responses in the expression of genes that act to maintain physiological homeostasis. We observed variation in plasma concentrations of high-density lipoprotein (HDL) cholesterol across inbred mouse strains in response to high dietary fat intake. Several strains, including C57BL/6J, have stable levels of plasma HDL independent of diet, whereas other strains, including DBA2/J, show marked changes in plasma HDL. To explore this phenomenon further, we used publicly available data from a C57BL/6J DBA/2J intercross to identify genetic factors that associate with HDL under high-fat diet conditions. Our analysis identified an epistatic interaction that plays a role in the buffering of HDL levels in C57BL/6J mice, and we have identified Arl4d as a candidate gene that mediates this effect. Structural modeling further elucidates the interaction of genetic factors that contribute to the robustness of HDL in response to high-fat diet in the C57BL/6J strain.
منابع مشابه
Epistasis contributes to the genetic buffering of plasma HDL cholesterol in mice.
Stressful environmental factors, such as a high-fat diet, can induce responses in the expression of genes that act to maintain physiological homeostasis. We observed variation in plasma concentrations of high-density lipoprotein (HDL) cholesterol across inbred mouse strains in response to high dietary fat intake. Several strains, including C57BL/6J, have stable levels of plasma HDL independent ...
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